Ö÷²¥ÓÕ»ó

Object moved to here.

Ö÷²¥ÓÕ»ó :: Pilot & Feasibility Program Application

Ö÷²¥ÓÕ»ó


Effect of Diabetes on Prostate Inflammation and Epithelial Hyperplasia
Summary Data Summary
Applicant Bushman, Wade
E-Mail Address bushman@urology.wisc.edu
Project Title Effect of Diabetes on Prostate Inflammation and Epithelial Hyperplasia
CBU ID 09MCG89
External SubContract ID 23789-12
Diabetic Complication Uropathy
Funding Program Group Pilot & Feasibility [PF2009]
Abstract Several studies have demonstrated a positive correlation of BMI with increased
prostate size and shown that men diagnosed with symptomatic benign prostatic
hyperplasia (BPH) have a higher incidence of diabetes than the general
population and that diabetes is associated with more severe symptoms.The
mechanism(s) for this association is unclear, although it has been postulated to
involve diabetes-associated inflammation and an associated stimulation of
prostatic hyperplasia. Even though clinical studies indicate significantly
increased risk of BPH and symptomatic progression in men with diabetes, there is
a remarkable dearth of laboratory studies on the effect of diabetes on prostate
inflammation and growth. Without this knowledge base, it is impossible to
speculate on the mechanisms by which diabetes may influence the growth of BPH or
the development of lower urinary tract symptomos or to speculate about possible
interventions to prevent or reverse these effects. There is, therefore, a
compelling need to expand laboratory studies of the prostate in diabetes and to
expand prostate research to include studies of prostatic inflammation and
neurophysiology in diabetic models.

Two specific aims address the hypothesis that diabetes is associated with
increased prostatic inflammation and hyperplasia. We will work with the members
of the AMDCC to select the appropriate transgenic models and perform the
following studies:

1. Test the hypothesis that diabetes is associated with increased prostatic
inflammation.
A. Use quantitative histologic scoring to compare prostatic inflammation in
young adult and older adult diabetic and control mice.
B. Use RT-PCR analysis to compare inflammatory mediator expression in young
adult and older adult diabetic and control mice.

2. Test the hypothesis that diabetes is associated with epithelial hyperplasia.
A. Use quantitative measurements to compare epithelial proliferation in young
adult and older adult diabetic and contol mice.
B. Use quantitative histologic scoring to compare the incidence of epithelial
hyperplasia in young adult and older adult diabetic and contol mice.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 12871
Supply Total Costs 22000
Equipment Total Costs 0
Travel/Other Total Costs 8000
Direct Costs 42871
Indirect Costs Proposed 16912
Total Costs Proposed 59783
Total Costs Approved 63000
Start Date 9/30/2009
End Date 8/31/2011
IFO Name Andresen, Robert
IFO E-Mail Address nih@rsp.wisc.edu
IACUC/IRB No. A3368-01
IACUC/IRB Institution University of Wisconsin-Madison
Entity ID No. 1-396006492-A1
Report Request Date 9/30/2011
T1D NO
TypeCount
Invoices 0
Progress Reports 2
Data Submission
Click here to cancel and return to funding program application

*Author:
*SubContract:
*Select File:

Click browse and select the file to upload.
(Please upload ONLY TXT, Image Files (not histolgy), PDF, XLS, XLSX, DOC, or DOCX files.)