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Imaging tools and models to study the effect of preterm birth on diabetic kidney disease
Summary Data Summary
Applicant Charlton, Jennifer
E-Mail Address jrc6n@hscmail.mcc.virginia.edu
Project Title Imaging tools and models to study the effect of preterm birth on diabetic kidney
disease
CBU ID 21AU4222
External SubContract ID 32307-97
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2021]
Abstract Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in
adults in the United States. There is an urgent unmet need to identify upstream
risk factors that influence the risk and progression of diabetic kidney disease.
This proposal will evaluate preterm birth as a significant risk factor in
diabetic kidney disease progression. Preterm birth is common with ~10% of live
births occurring before the 37th week of gestation. Those born preterm have an
increased risk to develop CKD, likely due to early cessation of nephrogenesis
and low nephron mass. Furthermore, studies have shown that preterm birth is a
risk factor for the development of type 2 diabetes mellitus (T2DM) and females
born early may be at greater risk for T2DM than preterm males. Neither clinical,
nor preclinical studies, have investigated the influence of a preterm birth in
the development or progression of diabetic kidney disease, representing a
significant knowledge gap. Our group has developed tools to address this
question and understand the molecular mechanisms that represent targetable
therapeutics in this patient population. This proposal will create and
investigate a diabetic mouse model born preterm using cutting-edge imaging and
gene expression techniques. In Aim 1, we will characterize the structural
phenotype of the kidney of a diabetic mouse model born preterm using cationic
ferritin enhanced-MRI. We will use cationic ferritin enhanced-MRI to measure the
glomerular number and spatially map size in diabetic mice born preterm. In Aim
2, we will compare the alterations of the kidney gene expression profiles in the
diabetic preterm mouse to the diabetic term mouse. The Aims of this study align
with the Diabetic Complications Consortium areas of emphasis both by advancing
imaging techniques to measure nephron number as an early marker of diabetic
kidney disease and examining sex differences in our model. At the conclusion of
this work, we will have a fully phenotyped diabetic preterm mouse model to test
therapeutic strategies for slowing progression in diabetic kidney disease.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 16516
Supply Total Costs 45403
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 61919
Indirect Costs Proposed 38081
Total Costs Proposed 100000
Total Costs Approved 60000
Start Date 7/1/2021
End Date 6/30/2023
IFO Name Bajaj, Urmila
IFO E-Mail Address osp-postaward@virginia.edu
IACUC/IRB No. 99999
IACUC/IRB Institution University of Virginia Health System
Entity ID No. 546001796
Report Request Date 6/30/2023
T1D NO
TypeCount
Invoices 14
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  21AU422232307-97University of Virginia Health System9/16/2022$14,516.10$8,927.43$23,443.53$238.27View PDF
  View  21AU422232307-97University of Virginia Health System8/15/2023$13.82$8.50$22.32$238.27View PDF
  View  21AU422232307-97University of Virginia Health System6/1/2022$1,523.80$937.14$2,460.94$238.27View PDF
  View  21AU422232307-97University of Virginia Health System5/4/2022$2,056.03$1,264.46$3,320.49$238.27View PDF
  View  21AU422232307-97University of Virginia Health System4/22/2022$2,494.16$1,533.91$4,028.07$238.27View PDF
  View  21AU422232307-97University of Virginia Health System3/31/2023$4,427.14$2,722.69$7,149.83$238.27View PDF
  View  21AU422232307-97University of Virginia Health System3/3/2022$1,314.34$808.32$2,122.66$238.27View PDF
  View  21AU422232307-97University of Virginia Health System2/8/2022$1,314.35$808.33$2,122.68$238.27View PDF
  View  21AU422232307-97University of Virginia Health System12/7/2022$3,780.61$2,088.18$5,868.79$238.27View PDF
  View  21AU422232307-97University of Virginia Health System12/17/2021$1,616.51$994.16$2,610.67$238.27View PDF
  View  21AU422232307-97University of Virginia Health System11/22/2021$1,314.41$808.36$2,122.77$238.27View PDF
  View  21AU422232307-97University of Virginia Health System10/4/2021$1,095.22$673.56$1,768.78$238.27View PDF
  View  21AU422232307-97University of Virginia Health System1/9/2023$672.11$413.34$1,085.45$238.27View PDF
  View  21AU422232307-97University of Virginia Health System1/11/2022$1,012.23$622.52$1,634.75$238.27View PDF
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