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Role of gut extracellular vesicles in the development of diabetic peripheral neuropathy
Summary Data Summary
Applicant Liu, Xianshuang
E-Mail Address xliu2@hfhs.org
Project Title Role of gut extracellular vesicles in the development of diabetic peripheral
neuropathy
CBU ID 21AU4165
External SubContract ID 32307-85
Diabetic Complication Neuropathy & Neurocognition
Funding Program Group Pilot & Feasibility [PF2021]
Abstract Peripheral neuropathy is one of the major complications of diabetes that greatly
contributes to morbidity and mortality. Currently, there is no effective
treatment for diabetic peripheral neuropathy (DPN). At early stage, diabetes
affects the intestinal microbial composition that drives the metabolic syndrome.
However, how gut dysbiosis contributes to the diabetic complication including
DPN has not been investigated. Extracellular vesicles (EVs) mediate
intercellular communication and bacterial EVs retain bacterial genetic and
biomaterials that are associated with many disorders. Recent studies show that
among many biological affects, gut microbiota-derived extracellular vesicles
(gut-EVs) participate in immune signaling pathways, host metabolic homeostasis,
and bacterial metabolite production. However, the impact of gut-EVs on DPN is
unknown. In the present study, we propose to investigate whether gut-EVs
contribute to the development of DPN, whereas probiotic-EVs alleviate DPN in
diabetic mice with peripheral neuropathy and its underlying molecular
mechanisms. These studies will not only significantly expand our understanding
of molecular mechanism underlying gut microbiota-peripheral nerve communication
and induction of DPN, but also provide a novel role of microbiota-derived EVs as
a new potential therapeutic strategy in the treatment of DPN and other
neurological disorders.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 44102
Supply Total Costs 22343
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 66445
Indirect Costs Proposed 33555
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 7/1/2021
End Date 6/30/2022
IFO Name Ohmer, Joe
IFO E-Mail Address johmer1@hfhs.org
IACUC/IRB No. 99999
IACUC/IRB Institution Henry Ford Hospital
Entity ID No. 1381357020A1
Report Request Date 6/30/2022
T1D NO
TypeCount
Invoices 3
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  21AU416532307-85Henry Ford Hospital8/23/2022$10,115.69$5,108.43$15,224.12-View PDF
  View  21AU416532307-85Henry Ford Hospital3/31/2022$23,686.10$11,961.48$35,647.58-View PDF
  View  21AU416532307-85Henry Ford Hospital1/7/2022$32,643.39$16,484.91$49,128.30-View PDF


Reports
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