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Defining Host-Microbiome Interctions in Diabetic Wound Healing
Summary Data Summary
Applicant Kalan, Lindsay
E-Mail Address lkalan@wisc.edu
Project Title Defining Host-Microbiome Interctions in Diabetic Wound Healing
CBU ID 18AU3885
External SubContract ID 32307-25
Diabetic Complication Wound Healing
Funding Program Group Pilot & Feasibility [PF2018]
Abstract Chronic non-healing wounds, such as diabetic foot ulcers, arise when normal
tissue repair processes are interrupted. These types of wounds are associated
with severe morbidity and diminished quality of life. Further, the microbiome of
chronic wounds is highly complex and diverse, comprising bacteria and fungi from
both unaffected skin and the environment. Current treatment strategies include
sharp debridement of wound tissue, aiming to both reduce microbial burden and
stimulate cellular regeneration by inducing an acute wound. However, the
mechanisms underlying this response are poorly characterized. Understanding how
the microbiome modulates host responses associated with tissue repair may lead
to novel diagnostic markers to predict healing outcomes. In this pilot study we
propose to employ dual transcriptome profiling (RNA-seq) of the host and
microbiome to simultaneously characterize host and microbial gene expression in
response to debridement. Our goal is to identify molecular signatures associated
with cellular responses to promote healing or microbial signatures associated
with impaired wound healing.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel Dr. Meghan Brennan
Salary Total Costs 22817
Supply Total Costs 16893
Equipment Total Costs 0
Travel/Other Total Costs 25650
Direct Costs 65360
Indirect Costs Proposed 34640
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 11/1/2018
End Date 10/31/2020
IFO Name Andresen, Robert
IFO E-Mail Address randresen@rsp.wisc.edu
IACUC/IRB No. 99999
IACUC/IRB Institution University of Wisconsin-Madison
Entity ID No. FWA00005399
Report Request Date 11/29/2020
T1D NO
TypeCount
Invoices 13
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  18AU388532307-25University of Wisconsin-Madison9/4/2019$699.41$370.68$1,070.09$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison9/3/2020$464.75$69.65$534.40$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison8/16/2019$4,843.20$2,566.88$7,410.08$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison5/4/2020$1,445.45$589.42$2,034.87$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison4/2/2020$15,233.11$7,896.88$23,129.99$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison3/3/2020$3,123.33$1,478.69$4,602.02$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison2/4/2020$2,160.27$968.27$3,128.54$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison12/3/2019$3,430.32$1,641.40$5,071.72$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison12/18/2020$20,730.51$10,810.52$31,541.03$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison11/4/2019$3,734.51$1,802.62$5,537.13$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison10/2/2020$1,424.96$578.57$2,003.53$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison10/2/2019$7,375.41$3,732.30$11,107.71$30.16View PDF
  View  18AU388532307-25University of Wisconsin-Madison1/3/2020$1,944.71$854.02$2,798.73$30.16View PDF
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