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Changes in energy generating pathways as a cause of diabetic bladder dysfunction.
Summary Data Summary
Applicant Davies, Kelvin
E-Mail Address kelvin.davies@einsteinmed.org
Project Title Changes in energy generating pathways as a cause of diabetic bladder
dysfunction.
CBU ID 16GRU3659
External SubContract ID 30835-9
Diabetic Complication Uropathy
Funding Program Group Pilot & Feasibility [PF2016]
Abstract Diabetes results in several bladder pathologies, a syndrome commonly referred to
as diabetic bladder disorder (DBD).There are at present no published studies
providing a global overview of changes in bladder metabolism resulting from
diabetes. Such studies have the potential to provide mechanistic insight into
the development of DBD and generate novel strategies for its treatment. In the
preliminary studies presented here we compared the metabolome of detrusor and
urothelial layer in a one month streptozotocin (STZ)-induced rat model of Type I
diabetes with non-diabetic controls. Diabetes caused several significant changes
in the metabolic profile of both tissues potentially related to DBD.However, DBD
is a progressive disease in both diabetic patients and animal models and
therefore expansion of these studies to consider temporal effects of diabetes on
bladder metabolism are warranted. In this proposal we will test the hypothesis
that diabetes leads to temporal progressive changes in bladder metabolism which
will associate with the development of the pathophysiology of DBD. We will test
this hypothesis in two Specific Aims. In Specific Aim 1 we will determine if
changes in the bladder metabolome occurs with hyperglycemia, but at a time point
prior to the exhibition of bladder pathophysiology. In order to do this we will
perform a metabolomics study after one week of Type I diabetes in the
STZ-induced rat model and determine if there are changes in the metabolism of
the bladder detrusor and urothelium compared to control non-diabetic rats. In
Specific Aim 2 we will determine if there are progressive changes in the bladder
metabolome caused by diabetes, as the bladder physiology progresses from the
compensated to decompensated state. However, when there are changes in the
physiology of the bladder, it would be difficult to distinguish which changes in
metabolism might be causative of, or a response to, pathophysiology. In an
attempt to identify metabolic changes that are a response to the decompensated
physiology (rather than due to hyperglycemia), we will look at those changes
that occur in the metabolome of the bladder in response to an aged matched
non-diabetic decompensated animal model (partial urethral obstruction of the
rat). The results from our studies have the potential to give novel insights
into the mechanisms leading to the development of DBD and identify novel
strategies that could be used to in its prevention and treatment.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 34970
Supply Total Costs 24910
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 59880
Indirect Costs Proposed 40120
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2016
End Date 9/30/2017
IFO Name Locke, Suzanne
IFO E-Mail Address suzanne.locke@einstein.yu.edu
IACUC/IRB No. 210121204
IACUC/IRB Institution Albert Einstein College of Medicine
Entity ID No. 41-2209056
Report Request Date 11/30/2017
T1D NO
TypeCount
Invoices 10
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  16GRU365930835-9Albert Einstein College of Medicine9/18/2017$16,338.97$10,947.10$27,286.07$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine7/20/2017$3,460.71$2,318.69$5,779.40$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine6/20/2017$2,790.86$1,869.87$4,660.73$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine5/17/2017$1,818.72$1,218.54$3,037.26$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine4/28/2017$1,399.37$937.57$2,336.94$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine3/22/2017$4,625.33$3,098.96$7,724.29$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine2/27/2017$1,399.36$937.56$2,336.92$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine12/16/2016$2,798.74$1,875.14$4,673.88$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine11/6/2017$23,848.72$15,978.70$39,827.42$0.17View PDF
  View  16GRU365930835-9Albert Einstein College of Medicine1/20/2017$1,399.36$937.56$2,336.92$0.17View PDF


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