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Molecular Mechanisms of Kidney Disease in Diabetes and Obesity
Summary Data Summary
Applicant Levi, Moshe
E-Mail Address moshe.levi@georgetown.edu
Project Title Molecular Mechanisms of Kidney Disease in Diabetes and Obesity
CBU ID 13GHSU256
External SubContract ID 25732-24
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2013]
Abstract The prevalence of obesity, insulin resistance, and diabetes mellitus is
increasing and becoming the leading causes of renal disease. In spite of all the
beneficial interventions implemented in patients with diabetes renal disease
still progresses in most of these patients. Additional treatment modalities that
modulate the pathogenic pathways involved in obesity and diabetic nephropathy
are therefore needed to slow the progression of renal disease. In this regard
recent studies in rodent models of diabetes indicate that a) nuclear receptors
including the farnesoid X receptor (FXR) and liver X receptor (LXR), b)
transcriptional factors including the sterol regulatory element binding proteins
(SREBPs), and c) G protein coupled receptors including TGR5 have highly
beneficial actions to prevent or slow down the progression of renal disease in
obesity and diabetes. However it is not known whether these pathways are altered
in human kidney disease in obesity and diabetes and whether the expression
levels and activity of these pathways correlate with renal histopathology. This
pilot grant will therefore address this important question.
In Specific Aim 1 we will extract mRNA, miRNA, and protein from fixed and
paraffin embedded human kidney biopsy samples from subjects with diabetic
nephropathy (DN), obesity related glomerulopathy (ORG), and normal kidneys from
samples are obtained from the Department of Pathology, Columbia University, NY,
USA, and Department of Pathology, Tel Aviv University, Tel Aviv, Israel. We will
analyze pathways related to a) fibrosis, b) oxidative stress, c) inflammation,
and d) lipid metabolism, as well as e) nuclear receptors, f) transcription
factors, and g) G protein coupled receptors that have been demonstrated to
regulate these important pathogenic factors.In Specific Aim 2 we will correlate
these molecular and metabolic pathways with estimated GFR, proteinuria, and
histopathology for each of the biopsy samples.In Specific Aim 3 we will study
the similarities and differences of gene expression secondary to a) type 2
diabetes mellitus and b) obesity without T2DM to study the effect of obesity in
the mechanism of diabetic nephropathy.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 19065
Supply Total Costs 36171
Equipment Total Costs 0
Travel/Other Total Costs 2000
Direct Costs 57236
Indirect Costs Proposed 42495
Total Costs Proposed 99731
Total Costs Approved 99731
Start Date 10/1/2013
End Date 9/30/2013
IFO Name Davis, Dianthony
IFO E-Mail Address xenia@ucdenver.edu
IACUC/IRB No. 9999
IACUC/IRB Institution University of Colorado
Entity ID No. A3269-01
Report Request Date 12/15/2014
T1D NO
TypeCount
Invoices 16
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU25625732-24University of Colorado9/25/2014$1,001.05-$1,001.05$322.51View PDF
  View  13GHSU25625732-24University of Colorado8/12/2014$1,018.95-$1,018.95$322.51View PDF
  View  13GHSU25625732-24University of Colorado7/25/2014$841.78-$841.78$322.51View PDF
  View  13GHSU25625732-24University of Colorado7/23/2015$14,975.33-$14,975.33$322.51View PDF
  View  13GHSU25625732-24University of Colorado6/17/2014$841.76-$841.76$322.51View PDF
  View  13GHSU25625732-24University of Colorado5/7/2015$3,311.00-$3,311.00$322.51View PDF
  View  13GHSU25625732-24University of Colorado5/16/2014$841.75-$841.75$322.51View PDF
  View  13GHSU25625732-24University of Colorado4/7/2014$545.67$297.39$843.06$322.51View PDF
  View  13GHSU25625732-24University of Colorado3/7/2014$544.83$296.93$841.76$322.51View PDF
  View  13GHSU25625732-24University of Colorado3/10/2015$48,301.00-$48,301.00$322.51View PDF
  View  13GHSU25625732-24University of Colorado2/26/2014$544.83$296.93$841.76$322.51View PDF
  View  13GHSU25625732-24University of Colorado2/22/2017---$322.51 
  View  13GHSU25625732-24University of Colorado12/13/2013$1,088.58$593.28$1,681.86$322.51View PDF
  View  13GHSU25625732-24University of Colorado10/6/2014$23,225.67-$23,225.67$322.51View PDF
  View  13GHSU25625732-24University of Colorado10/27/2015$34.26-$34.26$322.51View PDF
  View  13GHSU25625732-24University of Colorado1/13/2014$544.83$296.93$841.76$322.51View PDF


Reports
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