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Glucose Regulation of Hypertriglyceridemia
Summary Data Summary
Applicant Goldberg, Ira
E-Mail Address ira.goldberg@nyumc.org
Project Title Glucose Regulation of Hypertriglyceridemia
CBU ID 13GHSU231
External SubContract ID 25034-37
Diabetic Complication Cardiovascular
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Patients with metabolic syndrome (MetS), type 1 diabetes mellitus (T1DM), and
type 2 diabetes mellitus (T2DM) are at increased risk of cardiovascular disease
(CVD), but the underlying mechanisms remain poorly understood. Many lines of
evidence indicate that elevated levels of plasma triglyceride (TG) are causal,
especially in T2DM. Moreover, hypertriglyceridemia (hyperTG) is a likely cause
of changes in circulating levels of HDL cholesterol (HDL-C), a negative risk
factor for CVD. We propose to determine the pathophysiology responsible for
hyperTG in humans with diabetes and how hyperglycemia affects levels of plasma
TG and other lipoproteins. Moreover, we will assess whether hyperTG and diabetes
alter HDL function. This Pilot and Feasibility application has two specific
aims. Aim 1 is to determine why glucose reduction reduces TG levels in diabetic
mice. We will determine whether this is due to a reduction in TG production or
greater TG clearance. Aim 2 will determine the effects of acute hyperTG and
insulin-deficient diabetes on HDL composition and function. We will determine
the structural and lipid changes that occur in HDL from LpL-deleted mice and
whether these HDL are defective in promoting cholesterol efflux from
macrophages. The studies will lay the foundation for future investigations of
how altering circulating lipids in the setting of diabetes impact
atherosclerosis.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 45889
Supply Total Costs 8800
Equipment Total Costs 0
Travel/Other Total Costs 7811
Direct Costs 62500
Indirect Costs Proposed 37500
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2013
End Date 9/30/2015
IFO Name Berger, William
IFO E-Mail Address grants-office@columbia.edu
IACUC/IRB No. AAAF7055
IACUC/IRB Institution Columbia University
Entity ID No. 135598093
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 2
Progress Reports 3
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU23125034-37Columbia University7/25/2014$5,044.24-$5,044.24$2.49View PDF
  View  13GHSU23125034-37Columbia University12/7/2015$94,953.27-$94,953.27$2.49View PDF
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