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Kidney IRon by HAptoglobin genotype (KIRHA)
Summary Data Summary
Applicant Costacou, Tina
E-Mail Address costacout@edc.pitt.edu
Project Title Kidney IRon by HAptoglobin genotype (KIRHA)
CBU ID 15GHSU1478
External SubContract ID 25732-78
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2015]
Abstract Young adults with type 1 diabetes (T1D) exhibit dramatically higher cardiorenal
disease rates despite only minor risk factor differences vs. the general
population. Thus, there is a critical need to identify currently unrecognized
sources of increased susceptibility to vascular T1D complications. In the
absence of such knowledge, the development of effective prevention strategies to
address the excess cardiorenal rates in T1D will likely remain challenging. In
the past decade, the Haptoglobin (Hp) 2-2 genotype has risen as a major
contributor to T1D/T2D complication risk. Our long term goal is to identify the
mechanisms by which Hp 2-2 contributes to T1D/T2D cardiorenal risk, in order to
develop optimal intervention strategies to reduce/eliminate the genetic
susceptibility conferred by Hp 2-2. Our objective in this pilot study is to lay
the foundations for the identification of the biologic mechanisms by which this
established functional variant, Hp, affects predisposition to T1D kidney
disease. Our central hypothesis is that Hp 2-2 is associated with increased
kidney iron deposition and proximal tubular injury, leading to declining kidney
function and progression to end-stage renal disease (ESRD) in T1D. With this
project we will obtain preliminary data on kidney iron as well as on the
concentration of biomarkers of proximal tubular injury and oxidation by Hp
genotype 1-1 or 2-2 in individuals with T1D. Individuals with T1D and known Hp
genotype will be recruited from participants of the Pittsburgh Epidemiology of
Diabetes Complications (EDC) study (PI: Orchard) attending the 30 year follow-up
examination or from the HapE study (PI: Costacou). The preliminary data
generated in this project will aid the subsequent submission of an R01
application to fully assess this hypothesis in a larger sample, including all Hp
genotypes (1-1, 2-1 and 2-2) and also assessing the potential beneficial effects
of treatment with the antioxidant vitamin E (given existing data of benefit
against coronary heart disease among those with diabetes and Hp 2-2) and/or
chelation therapy (in which the consortium has expressed interest) in the
genetically susceptible group with T1D and the Hp 2-2 genotype (>40% of the T1D
population).
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 44137
Supply Total Costs 238
Equipment Total Costs 0
Travel/Other Total Costs 26801
Direct Costs 71176
Indirect Costs Proposed 28734
Total Costs Proposed 99910
Total Costs Approved 99910
Start Date 10/1/2015
End Date 12/31/2016
IFO Name Woodward, Jennifer
IFO E-Mail Address offres@offres.pitt.edu
IACUC/IRB No. 99999
IACUC/IRB Institution University of Pittsburgh-Main Campus
Entity ID No. 1250965591A6
Report Request Date 12/31/2016
T1D NO
TypeCount
Invoices 10
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus9/25/2017$11,888.08$6,597.89$18,485.97$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus8/8/2016$5,810.44$2,258.80$8,069.24$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus7/11/2016$9,914.98$2,541.78$12,456.76$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus6/15/2016$9,305.09$3,267.06$12,572.15$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus5/9/2016$6,754.21$2,768.43$9,522.64$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus4/11/2016$4,110.67$2,219.77$6,330.44$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus3/9/2016$4,000.14$2,160.07$6,160.21$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus3/27/2018$8,686.00-$8,686.00$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus2/8/2016$3,379.57$1,824.97$5,204.54$246.91View PDF
  View  15GHSU147825732-78University of Pittsburgh-Main Campus10/24/2016$10,575.42$1,599.72$12,175.14$246.91View PDF


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