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The Role of Oxidative Stress in Diabetes Induced Progenitor Cell Deficits
Summary Data Summary
Applicant Gurtner, Geoffrey
E-Mail Address ggurtner@stanford.edu
Project Title The Role of Oxidative Stress in Diabetes Induced Progenitor Cell Deficits
CBU ID 14GHSU1458
External SubContract ID 25732-57
Diabetic Complication Wound Healing
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Diabetes affects 25.8 million people in the United States (8.3% of the
population), and is particularly detrimental to the vascular system. Our
laboratory has delineated specific and discrete defects in a number of
stem/progenitor cell populations in diabetes that may underlie impaired wound
healing and neovascularization. We have also recently identified the enzyme
glyoxalase 1 (Glo1) (a regulator of glycolysis-derived methylgloxal [MG]
formation and production of reactive oxygen species [ROS]) as a critical
regulator of diabetic vascular and end organ dysfunction. In this proposal, we
build on these novel findings to test our fundamental hypothesis that diabetic
progenitor cell defects are the result of MG-induced oxidative stress, and that
normalization of this stress through modulation of the MG-regulating enzyme Glo1
will prevent and reverse diabetic progenitor cell defects and wound healing
sequelae. This work will determine whether restoration of progenitor defects by
reducing MG-derived ROS is a clinically viable strategy to treat diabetic
complications.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 37918
Supply Total Costs 5621
Equipment Total Costs 0
Travel/Other Total Costs 18691
Direct Costs 62230
Indirect Costs Proposed 37770
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2014
End Date 9/30/2015
IFO Name Collum, Sharon
IFO E-Mail Address slcollum@stanford.edu
IACUC/IRB No. A3213-01
IACUC/IRB Institution Stanford University
Entity ID No. 194115636A1
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 15
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU145825732-57Stanford University9/30/2016$2,577.11$1,520.47$4,097.58$0.03View PDF
  View  14GHSU145825732-57Stanford University7/31/2016$1,825.69$1,077.15$2,902.84$0.03View PDF
  View  14GHSU145825732-57Stanford University6/30/2016$1,825.56$1,077.08$2,902.64$0.03View PDF
  View  14GHSU145825732-57Stanford University6/30/2015$12,077.33-$12,077.33$0.03View PDF
  View  14GHSU145825732-57Stanford University5/31/2016$1,825.58$1,077.10$2,902.68$0.03View PDF
  View  14GHSU145825732-57Stanford University5/31/2015$3,898.58-$3,898.58$0.03View PDF
  View  14GHSU145825732-57Stanford University4/30/2016$1,825.57$1,077.09$2,902.66$0.03View PDF
  View  14GHSU145825732-57Stanford University4/30/2015$945.82-$945.82$0.03View PDF
  View  14GHSU145825732-57Stanford University3/31/2016$1,825.57$1,077.09$2,902.66$0.03View PDF
  View  14GHSU145825732-57Stanford University3/31/2015$5,625.81-$5,625.81$0.03View PDF
  View  14GHSU145825732-57Stanford University2/29/2016$1,825.57$1,077.09$2,902.66$0.03View PDF
  View  14GHSU145825732-57Stanford University2/28/2015$49,594.66-$49,594.66$0.03View PDF
  View  14GHSU145825732-57Stanford University12/31/2015$538.55-$538.55$0.03View PDF
  View  14GHSU145825732-57Stanford University1/31/2016$2,902.66-$2,902.66$0.03View PDF
  View  14GHSU145825732-57Stanford University $1,825.69$1,077.15$2,902.84$0.03View PDF
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