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Nephron progenitor culture technology for ex vivo nephrogenesis
Summary Data Summary
Applicant Oxburgh, Leif
E-Mail Address leo9022@nyp.org
Project Title Nephron progenitor culture technology for ex vivo nephrogenesis
CBU ID 14GHSU1442
External SubContract ID 25034-50
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Diabetes strongly predisposes to chronic kidney disease, which afflicts
approximately 10% of the adult population of the US. Because nephrogenesis is
limited to the fetal period, severely damaged nephrons cannot be replaced in the
adult human. Chronic kidney disease patients who do no retain sufficient
functional kidney mass to sustain physiological function therefore require
lifelong renal replacement therapy. Dialysis filters excess urea from the blood,
but does not provide all of the physiological functions of the kidney, and a
kidney transplant is often required as functional renal mass decreases. However,
the demand for kidney transplants far exceeds availability. Technology for de
novo nephrogenesis would enable therapeutic replacement of damaged kidney
tissue, and would also provide human tissue with which we could study kidney
development and the origins of kidney disease. We propose to systematic develop
a procedure for propagation of pure nephron progenitor cells from mouse and
human that can be used for bioengineering and engraftment studies. This project
aims to provide a highly accessible method that will accelerate research on
regenerative therapies for chronic kidney disease.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 46164
Supply Total Costs 28660
Equipment Total Costs 0
Travel/Other Total Costs 4360
Direct Costs 79184
Indirect Costs Proposed 15837
Total Costs Proposed 95021
Total Costs Approved 95021
Start Date 10/1/2014
End Date 9/30/2014
IFO Name Stevens, Stephanie
IFO E-Mail Address steves@mmc.org
IACUC/IRB No. 1302
IACUC/IRB Institution Maine Medical Center Research Institute
Entity ID No. A3862-01
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 8
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU144225034-50Maine Medical Center Research Institute8/18/2015$18,705.52-$18,705.52$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute4/13/2015$4,419.68-$4,419.68$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute3/18/2015$5,221.33-$5,221.33$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute2/18/2015$13,894.88-$13,894.88$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute12/18/2014$6,803.46-$6,803.46$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute11/17/2014$12,908.25-$12,908.25$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute10/13/2015$23,581.16-$23,581.16$4,930.34View PDF
  View  14GHSU144225034-50Maine Medical Center Research Institute1/15/2015$4,556.38-$4,556.38$4,930.34View PDF


Reports
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