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Hyperglycemia and diabetic kidney and nerve disease
Summary Data Summary
Applicant Sharma, Kumar
E-Mail Address kusharma@ucsd.edu
Project Title Hyperglycemia and diabetic kidney and nerve disease
CBU ID 10MCG132
External SubContract ID 24020-1
Diabetic Complication Nephropathy
Funding Program Group Summer Student Opportunities [SS2010]
Abstract The proposed summer student application will seek to mine the AMDCC database to
evaluate two key questions, 1. Does the degree of hyperglycemia correlate with
the diabetic kidney and nerve complications, and 2. Are features of diabetic
kidney and nerve disease track with each other? To answer these questions there
will be a joint mentorship to guide several talented students for the summer
period. Several new mouse models with diabetes have been developed by the AMDCC
and their data has been deposited in the AMDCC website. With the information
already available, the question of whether the plasma glucose levels across the
duration of diabetes will be correlated with albuminuria and plasma creatinine
levels (as markers of kidney function) as well as nerve conduction velocity and
sensory loss (as markers of neuropathy) in aim 1. In aim 2, the data describing
the quantitation of albuminuria and mesangial matrix will be correlated with
nerve dysfunction. Data will be analyzed with the assistance of a tema of
mentors that will include Dr. Sharma (for nephropathy), Dr. Nigel Calcutt for
neuropathy, Dr. Tim Ravasi (for bioinformatic support) and Dr. Ronghui (Lily) Xu
(for biostatistical support). Students will include one college student and two
high school students who have some expertise basic biology research,
bioinformatic analysis, and mouse models.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 3000
Supply Total Costs 0
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 3000
Indirect Costs Proposed 0
Total Costs Proposed 3000
Total Costs Approved 3000
Start Date 6/1/2010
End Date 9/30/2010
IFO Name Wheaton, Judith
IFO E-Mail Address jwheaton@ucsd.edu
IACUC/IRB No. 1234567
IACUC/IRB Institution University of California San Diego
Entity ID No.
Report Request Date 11/15/2010
T1D NO
TypeCount
Invoices 0
Progress Reports 1
Data Submission


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